Kifunensine, (+)- - FR 900494

Name	KIFUNENSINE
Synonyms	FR 900494 KIFUNENSINE [5R-(5α,6β,7α,8α,8aα)]- Kifunensine, (+)- - FR 900494 (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione FR 900494, Hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a] pyridine-2,3-dione (5R,8aS)-1,5,6,7,8,8a-Hexahydro-6β,7α,8α-trihydroxy-5α-(hydroxymethyl)imidazo[1,2-a]pyridine-2,3-dione
CAS	109944-15-2

Molecular Formula	C8H12N2O6
Molar Mass	232.19
Density	1.85±0.1 g/cm3(Predicted)
Melting Point	>280°C
Solubility	water, double-distilled: soluble50MM
Appearance	White solid
Color	White
pKa	9.61±0.70(Predicted)
Storage Condition	−20°C
Stability	Desiccate and Store at -20°C

WGK Germany

biological activity	Kifunensine is a potent and selective inhibitor of class I α-mannosidases that can be isolated from Actinomycetes, the α-mannosidases I can be blocked from pruning mannose residues on glycoproteins. Kifunensine inhibits the endoplasmic reticulum-related protein degradation pathway.
Cell Line:	Hybridoma cells expressing a human IgG1 monoclonal Antibody [3] .
Concentration:	2 μg/mL.
Incubation Time:	4 days.
Result:	Significantly reduced the lentil lectin binding. Kifunensine is the most effective among the inhibitors tested in producing antibodies containing oligomannose residues without fucose. There was no significant difference in the serum levels of anti-TEM B mAb generated from cells treated with or without kifunensine in the 7-day period.
Animal Model:	BALB/c mice.
Dosage:	5 mg/kg.
Administration:	IV via tail vein.

Last Update：2024-04-09 20:49:11

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CAS: 109944-15-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

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Product Name: KIFUNENSINE Visit Supplier Webpage Request for quotation
CAS: 109944-15-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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Kifunensine, (+)- - FR 900494

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